Sumatriptan: Side Effects, Dosage, Mechanism of Action, and More
HealthlineUniversity of Illinois
Sumatriptan: Side Effects, Dosage, Mechanism of Action, and More
Sumatriptan oral tablets (Imitrex) are used to treat migraine episodes. Learn about side effects, warnings, dosage, and more.
Dec 10, 2024
Sumatriptan Side Effects
Can Sumatriptan Cause Worse Headaches
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⚡ Acute Severe Migraine Treatment 🦠 First-Line Options 📍 Triptans (5-HT1B/1D agonists): Sumatriptan (oral, nasal, SC), rizatriptan, eletriptan - abort migraine by causing cerebral vasoconstriction and blocking pain pathways - most effective within 2 hours of onset 📍 CGRP antagonists (gepants): Ubrogepant, rimegepant (oral) - block CGRP receptor, no vasoconstriction - safe alternative when triptans contraindicated (CV disease, uncontrolled HTN) 🦠 Second-Line/Combination Therapy 📍 NSAIDs (hig
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