Video: Preparation of Amines: Reductive Amination of Aldehydes and Ketones

SOLVED:The reductive amination shown was a key step in the synthesis of a compound for testing as an analgesic. Write a structural formula for this compound.

(i) Reductive amination : In these processes, ammonia reacts wi... | Filo

Title: Reductive Amination: Mechanism and Limiting Reagent Calc... | Filo

Reductive amination of excess formaldehyde with a primary amine... | Filo

SOLVED:One problem with reductive amination as a method of amine synthesis is that by-products are sometimes obtained. For example, reductive amination of benzaldehyde with methylamine leads to a mixture of N -methylbenzylamine and N -methyldibenzylamine. How do you suppose the tertiary amine by-product is formed? Propose a mechanism.

SOLVED: Draw structural formulas for the two compounds you could use to prepare the amine shown by reductive amination You do not have to consider stereochemistry: Do not include the reducing agent your answer If there is more than one combination draw only one Draw one structure per sketcher: Add additional sketchers using the drop-down menu in the bottom right corner: Separate multiple reactants using the sign from the drop-down menu: