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✨Complement Coagulation Pathway✨ 🔸Interconnection between two major plasma cascade systems in the body: the Complement system (innate immunity) and the Coagulation system (blood clotting). 💐Complement Pathway💐 3 activation routes, all converging at the formation of C3 convertase → C5 convertase → Membrane Attack Complex (MAC, C5b–9): 🔸1.Classical pathway → triggered by Ag–Ab complexes (IgG, IgM) 🔸2.Lectin pathway → triggered by Mannose-binding lectin (MBL) 🔸3.Alternative pathway → triggere
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Moderate-to-severe hemophilia B requires continuous coagulation factor IX replacement to prevent bleeding. It is unknown whether gene therapy could obviate the need for factor IX replacement. New research findings are summarized in a short video. https://nej.md/3Z6hdtw | The New England Journal of Medicine
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