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Proton pump inhibitors are effective medications — and they absolutely have a role. But long-term, unchecked use raises concerns we don’t talk about enough. Common PPIs include: Prilosec (omeprazole), Nexium (esomeprazole), Protonix (pantoprazole), Prevacid (lansoprazole), Dexilant (dexlansoprazole) PPIs do not clearly cause cancer — but long-term use has been associated with: • chronically elevated gastrin levels • altered stomach and gut microbiome • potential nitrosamine formation • masking s