Modern machine learning approaches have shown remarkable success in extracting patterns from high-dimensional biological data. However, when applied to spatial transcriptomics, these methods face ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

The evolution of single-cell sequencing and spatial omics technologies has revolutionised our ability to study tissues and diseases with unprecedented resolution. It has long been recognised that gene ...

Transcriptomics represents a critical discipline in cancer research, enabling comprehensive mapping of gene expression profiles and the identification of fusion genes implicated in tumor development.

Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Stem cells in most organisms typically take cues from adjacent cells. But new research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and ...

Do you want to generate spatial transcriptomics data using your H&E images? We introduce DeepSpot, a novel deep-learning model that predicts spatial transcriptomics from H&E images. DeepSpot employs a ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...

Spatial transcriptomics enables researchers to measure gene expression in tissue sections while preserving their spatial organisation. Unlike traditional RNA sequencing, which requires dissociating ...

College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China Zhejiang Key Laboratory of Intelligent Manufacturing for Functional Chemicals, ZJU-Hangzhou Global ...

bDepartment of Intensive Care Medicine, Nepean Hospital, Sydney, NSW, Australia cThe University of Sydney Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, ...