New Study Shows SIK1 Strengthens Antiviral Immunity to Limit EV-D68–Induced Asthma Exacerbations Asthma is a chronic ...

Increased BMI and IBD have causal effects on the risk of hidradenitis suppurativa, as shown by Mendelian randomization analysis. Moderate genetic correlations were found between HS and BMI, smoking, ...

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The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...

We identify six causal molecular biomarkers (e.g., CNPY4, ENTPD6, HLA-A) and eight clinical biomarkers (e.g., serum total protein) for MASLD across various independent cohorts. Serum total protein ...

In Mendelian inheritance patterns, you receive one version of a gene, called an allele, from each parent. These alleles can be dominant or recessive. Non-Mendelian genetics don’t completely follow ...

Background: Observational studies have indicated a potential association between ankylosing spondylitis and elevated cardiovascular disease (CVD) risk. However, it remains uncertain whether this ...

Imagine this: you’re in the middle of an important project, juggling deadlines, and collaborating with a team scattered across time zones. Suddenly, your computer crashes, and hours of work vanish in ...

A Mendelian randomization analysis of genome-wide association study (GWAS) data investigated the potential causal links between gut microbiota composition and symptoms of obsessive-compulsive disorder ...

A new genetic study shows that just one extra cup of instant coffee a day could significantly increase your risk of developing dry AMD, shedding fresh light on how our daily beverage choices may shape ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. The authors performed ...