Genome-wide association studies (GWAS) are widely used to uncover novel genetic susceptibility loci for complex genetic diseases. If the true genetic model is known, the association test reflecting ...

This is a preview. Log in through your library . Abstract This paper is concerned with the modeling and analysis of data collected in a large experiment designed to study the mortality in gypsy moths ...

Various methods have been proposed for smoothing under the monotonicity constraint. We review the literature and implement an approach of monotone smoothing with B-splines for a generalized linear ...

The GENMOD procedure fits a generalized linear model to the data by maximum likelihood estimation of the parameter vector .There is, in general, no closed form solution for the maximum likelihood ...

The correlations between the counts are modeled as , (exchangeable correlations). For comparison, the correlations are also modeled as independent (identity correlation matrix). In this model, the ...