UCSF scientists have developed a “molecular GPS” to guide immune cells into the brain and kill tumors without harming healthy tissue. It is the first living cell therapy that can navigate through the ...

Cancer treatment with a cell-based immunotherapy causes mild cognitive impairment, a Stanford Medicine team found. They also identified compounds that could treat it. After treatment with CAR-T cells ...

A dual-target CAR T cell therapy approach shows promise for slowing tumor growth in a notoriously aggressive and fast-growing brain cancer. Tumors became smaller after the experimental CAR T cell ...

Researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time. The organoid's response to ...

“It really tells us it's not about the genetics [of the tumor],” said Joyce. “It's really about the microenvironment, and the brain microenvironment is profoundly more immune suppressive than in ...

After treatment with CAR-T cells—immune cells engineered to attack cancer—patients sometimes tell their doctors they feel like they have “brain fog,” or forgetfulness and difficulty concentrating. A ...

Filippo Beleggia, MD, PhD, didn’t believe his own data. As a postdoctoral researcher, he spent years in the laboratory of Christian Reinhardt, MD, PhD, at the University Hospital Cologne, Cologne, ...

In an early-stage clinical trial, the therapy nearly doubled the expected survival time of young patients. Still, experts caution that more research is needed. Gavin Nielsen was 2 years old when he ...

A group of Penn researchers found that a common blood pressure medicine can be used to prevent brain cancer cells from growing. After trying to understand how the drug, hydralazine, works at a ...