Nature

Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

Mitochondrial aconitase is sensitive to oxidative inactivation and can aggregate and accumulate in many age-related disorders. Here we report that Lon protease, an ATP-stimulated mitochondrial matrix ...
Nature

Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species

Mitochondrial Lon operates in protein quality control and stress response pathways in mitochondria by its multiple functions. 17, 18, 19, 20 In addition to its ...
PBS

The Man of a Thousand Faces

American Masters – Lon Chaney: A Thousand Faces premiered on PBS in 2000. When we think of the silent film era, we think of actors like Charlie Chaplin, Buster Keaton, or Clara Bow, stars who created ...