Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

* One sperm donor was linked to nearly 200 births across multiple countries * Several children inherited a high-risk TP53 cancer mutation * Case exposes gaps in genetic screening //and donor ...

Higgins is an advocate for people with Li-Fraumeni syndrome. I was born with an inherited cancer syndrome, Li-Fraumeni syndrome (LFS). A mutation on my Tp53 cancer suppressor gene makes me susceptible ...

Patients with TP53 germline variants have an increased risk of secondary sarcoma post-radiation therapy. The 15-year risk of sarcoma for TP53 pathogenic variant carriers is 8.8%, higher than the ...