Nature

Only a single codon in the gene sequence is changed in base substitution mutation.

Just like the mechanical components in cars or computers, the molecules inside a cell can sometimes malfunction. When this happens during DNA replication, the result is an unpredictable change in the ...
Nature

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

We set out to determine the quantity and map the profile of spontaneous mutations arising in wild-type (WT) and BRCA1 or BRCA2 mutant cells. We used a chicken DT40 cell line carrying a homozygous ...