Using gene editing in a preclinical model, researchers at UT Southwestern Medical Center blocked the symptoms of a rare smooth muscle disease before they developed. Their findings, published in ...
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
The same model also allows exploration of CICR in neurons, smooth muscle, and immune cells, expanding its clinical impact. With this insight, drug design can now focus on precision control of Ca²⁺ ...
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
A new study shows targeting a protein in smooth muscle cells can block and decrease buildup of atherosclerotic plaque in mouse models, according to researchers. A new study shows targeting a protein ...
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