New Cell-Based Assays Support Drug Discovery Across the Amylin Receptor Family STATE COLLEGE, PA, UNITED STATES, ...

The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

Laboratory tests of a novel serotonin-binding compound have revealed an unexpected disconnect between receptor activation and ...

Researchers have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a new study. The findings hold ...

Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

CAR architecture has evolved through four generations. The first relied solely on CD3ζ and lacked potency. Second-generation receptors added either CD28 or 4-1BB costimulation, striking a balance ...

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target ...

Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice. Researchers at the NYU Pain Research Center have found a new receptor for ...