The phase 3 KANDLELIT-007 trial (NCT07190248) evaluating the KRAS G12C inhibitor calderasib (MK-1084) plus subcutaneous pembrolizumab and berahyaluronidase alfa-pmph (Keytruda Qlex; SC pembrolizumab) ...

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by ...

A protein once thought to simply help cancer cells avoid death turns out to do much more. MCL1 actively drives cancer ...

Cell signalling pathways are central to maintaining cellular homeostasis and regulating essential functions such as proliferation, apoptosis, and repair. In both cancer and neurodegenerative diseases, ...

A study led by researchers at Moffitt Cancer Center found that normal cells surrounding a tumor, known as cancer-associated ...

A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...

Gastric cancer cells can activate KRAS-driven signals, enabling autonomous tumor growth by producing their own WNT proteins. New research reveals how gastric cancer cells exploit WNT signaling for ...

A new study reveals how a single cancer protein may simultaneously drive tumor survival and metabolic control, uncovering a ...

Researchers have shown that the protein MCL1 not only inhibits programmed cell death, but also plays a central role in tumor ...

Gastric (stomach) cancer remains one of the most common and deadly cancers in East Asia, including Korea. Yet despite its ...