Potassium channels can become nonconducting via inactivation at a gate inside the highly conserved selectivity filter (SF) region near the extracellular side of the membrane. In certain ligand-gated ...

Anu Tyagi, Tofayel Ahmed, Shi Jian, Saumya Bajaj, Seow Theng Ong, Stephanie Shee Min Goay, Yue Zhao, Igor Vorobyov, Changlin Tian, K. George Chandy, Shashi Bhushan Proceedings of the National Academy ...

Researchers reveal how the presence of bulky aromatic amino acids at positions 1 and 3 of the aromatic/arginine selectivity filter determines urea and boric acid permeability in Aquaporin 10 paralogs.

Do only potassium ions pass through the selectivity filter of a potassium channel, or are there water molecules between the ions? This question has been a source of controversy for years. Researchers ...