Test time has arrived: the first person has been treated in a highly anticipated gene therapy trial that aims to coax aged cells to take on a younger identity. The clinical trial will test a novel ...

Aging, at its most fundamental level, is a molecular process. Chemical marks on the genome shift and lose fidelity over time, ...

Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.

EPFL researchers have uncovered how transcription factor dosage reshapes cell identity, showing that even small differences in dose can steer cells toward completely different fates. Their findings ...

A gastrointestinal oncologist told Newsweek that the early-stage findings are a “major step forward” in targeting colon ...

In a breakthrough for longevity science, a reverse-aging treatment has been injected into a human. The technique is a sought-after solution for improving longevity by reprogramming cells. Competitors ...

Cell therapy, particularly using cardiomyocytes, shows significant promise for treating heart failure. Direct reprogramming of somatic cells into cardiomyocytes using small molecules is advantageous ...

In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the "recipe" for the transformation. Researchers at Lund University have now created ...

Decoding and reprogramming cells — the fundamental units of life — remains one of the most profound challenges in modern biology. Historically, the identity of a differentiated cell was viewed as ...

Researchers at Oregon Health & Science University have uncovered a key reason why immunotherapy has largely failed in pancreatic cancer—and identified a promising strategy to overcome that resistance.

In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the "recipe" for the transformation. Researchers at Lund University have now created ...

In recent years, we have come to appreciate that loss or dysfunction of insulin-producing islet beta cells underlies virtually all major forms of diabetes mellitus. In type 1 diabetes, beta cells ...