The metanephros is formed from the reciprocal inductive interaction of two precursor tissues, the metanephric mesenchyme (MM) and the ureteric bud (UB). The UB induces MM to condense and differentiate ...

Serial infusions to restore amniotic fluid lost due to lack of fetal renal development before 26 weeks' gestation improved the rate of live births without maternal safety risks, the RAFT trial found.

In a first-of-its-kind look at human kidney development, researchers have isolated human nephron progenitor (NP) cells. Their results will help scientists understand how these progenitor cells become ...

Senior Postdoctoral Research Fellow, GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Children's Hospital Los Angeles The extracellular matrix (ECM) is a ...

We agree that conducting dedicated renal impairment trials is cumbersome during oncology drug development. As Beumer at al 5 highlight, is it difficult to enroll patients in the severe impairment ...

Besides being underweight, babies born to women whose diet lacked sufficient protein during pregnancy tend to have kidney problems resulting from alterations that occurred while their organs were ...

A new mouse metanephric organ culture system has been developed to study mammalian renal development. The system permits in vitro organotypic differentiation in a serum-free, hormone supplemented ...

Congenital heart defects (CHD) are developmental and functional abnormalities of an infant's heart at birth. CHD are the most common type of birth defect affecting approximately 1 in every 115 babies.