Rare disease research operates under conditions of extreme complexity. These pressures are driving new approaches to evidence generation, trial design and regulatory thinking that could influence the ...

May 12, 2026 expert reaction to an RCT on using orforglipron for maintenance of body weight reduction after weight loss using injectable tirzepatide or semaglutide . A randomised ...

Objective To perform a large-scale pairwise and network meta-analysis on the effects of all relevant exercise training modes on resting blood pressure to establish optimal antihypertensive exercise ...

Objective To investigate the effectiveness of cryotherapy on pain intensity, range of motion (ROM), swelling and function in the postoperative care of musculoskeletal disorders. Design Systematic ...