Phase I dose-finding studies aim at identifying the maximum tolerated dose (MTD). Often, several dose-finding studies are conducted with some variation in the administration mode or dose panel. For ...

Background The role of mineralocorticoid receptor antagonists (MRAs) in acute myocardial infarction (MI) remains controversial, with conflicting evidence from landmark trials. We aimed to assess the ...

Objective To perform a large-scale pairwise and network meta-analysis on the effects of all relevant exercise training modes on resting blood pressure to establish optimal antihypertensive exercise ...

Objective To examine the effect of exercise during the first year postpartum on pelvic floor disorders and diastasis recti abdominis. Design Systematic review with random effects meta-analysis. Data ...

Meta-analysis is an objective examination of published data from many studies of the same research topic identified through a literature search. Through the use of rigorous statistical methods, it can ...