Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

A mechanism by which knockouts of maternal mRNA clearing factors lead to zygotic arrest in mice. Abnormal accumulation of maternal mRNAs in mouse zygotes leads to transcriptional leakage before the ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...