First-in-Class Oral PKM2 Modulator SYX-5219 Phase 1a Trial Data to be Presented at SID 2026

First-in-human healthy volunteers trial showed SYX-5219 was safe and well toleratedSystemic immunomodulation of type 2 inflammation demonstrated ...

MIRA Pharmaceuticals Reports Positive Unblinded Phase 1 Data for Ketamir-2

Selective oral NMDA receptor modulator demonstrated favorable safety, tolerability, and pharmacokinetic profile supporting planned Phase 2a development in chemotherapy-induced peripheral neuropathy ...
Phys.org

Broadband low-loss all-optical phase modulator using gas-filled hollow-core fiber

Schematic diagram (a) and photo (b) of the fabricated gas-filled hollow-core fiber phase modulator. (c) Measured loss spectrum and (d) transient response of the phase modulator. Credit: ...
Nasdaq

Septerna Announces Dosing of the First Participants in Phase 1 Clinical Trial of SEP-631, an Oral Small Molecule MRGPRX2 Negative Allosteric Modulator for the Treatment of Mast ...

SOUTH SAN FRANCISCO, Calif., Aug. 21, 2025 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug ...
Monthly Prescribing Reference

Negative Allosteric Modulator Candidate Misses Endpoints in Social Anxiety Disorder Trial

Neuphoria’s social anxiety disorder program will be discontinued based on the results from the AFFIRM-1 trial. Topline results were announced from a phase 3 trial evaluating BNC210 in patients with ...
EurekAlert!

Chip-scale polydimethylsiloxane acousto-optic phase modulator boosts higher-resolution plasmonic comb spectroscopy

This study demonstrates a compact optical modulation platform that enables real-time, high-resolution spectroscopy using sub-MHz interleaved combs generated via chip-scale acousto-optic phase ...