Researchers have deciphered the long-sought atomic structure of PRC2, an enzyme complex that plays a key role in the development of several types of cancer, in particular blood cancer. Researchers at ...

The histone methyltransferase Polycomb repressive complex 2 (PRC2) represses transcription by catalysing the trimethylation of histone H3 Lys27 (H3K27me3). The complex can contain either of two ...

A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) ...

Lab scientists use cryo-electron microscopy to gain a deeper understanding of the structure of a regulatory complex. Their research could open up new possibilities for cancer therapies. All the ...

All the trillions of cells in our body share the same genetic information and are derived from a single, fertilized egg. When this initial cell multiplies during fetal development, its daughter cells ...