Nancy Dreyer, PhD, MPH, FISE, chief scientific advisor to Picnic Health, shares some of the ways that direct-to-patient approaches have improved observational research. Direct-to-patient approaches ...

Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome Comparative efficacy ...

Observational studies are critical in evaluating the long-term safety and effectiveness of new therapies on patients’ lives. However, two major shifts are significantly changing the research ...

The goal of comparative effectiveness research is to inform clinical decisions between alternate treatment strategies using data that reflect real patient populations and real-world clinical scenarios ...

• The choice between an observational study and a randomized controlled trial (RCT) is not binary. • No algorithm exists for determining whether an observational study or an RCT is best for answering ...

Randomized controlled trials (RCTs) are considered superior to observational studies, and both clinicians and researchers believe that conclusions that stem from observational research are flawed.

Decades of research have established a significant link between physical activity and health, influencing agenda setting, policy making and community awareness.1–4 However, the field continues to ...