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NFL Week 18 is here, so let's look at the odds and make some picks and predictions for the coming weekend as the playoffs near.

It's Week 18 of the 2025 NFL season and the regular season comes to a close with plenty to play for around the league. The action starts on Saturday with the Carolina Panthers visiting the Tampa Bay Buccaneers with the NFC South on the line and wraps up Sunday night with the Pittsburgh Steelers hosting the Baltimore Ravens for the AFC North title.

The NFL playoff picture will finalize after the NFL Week 18 schedule. The top seeds in both the AFC and NFC are still at stake, as is who is going to take the NFC South and AFC North title and the playoff spot that comes with it.

NFL Week 17 is here, so let's look at the odds and make some picks and predictions for the coming weekend as the playoffs near.

Matthew Stafford or Drake Maye? That’s the question that NFL MVP voters will be asking themselves after Week 18, but the betting market has picked a side.  Staf

It's true the Titans secondary is occupied by practice squad players, but 13.5 points is a lot. I'm not calling for an upset, but don't forget that this Jaguars team has lost to the Titans in a critical Week 18 spot before.

Los Angeles opened as a 10-point favorite in Carolina at BetMGM, and the line has moved to -10.5 (and even up to -11 at some books). If that line holds, it would make the Rams the biggest playoff road favorite in the Super Bowl era, according to Sports Odds History — which goes all the way back to 1966.