Mechanisms behind tumor suppressor BAP1 highlight new treatment strategies for aggressive cancers

A team of scientists led by the National Cancer Center Singapore (NCCS) and Duke-NUS Medical School (Duke-NUS) has found a ...
Yale Environment 360

Change trackers: New consortium to catalog DNA mutations across human lifetime

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body’s typically efficient DNA repair machinery and potentially affecting our health ...
ascopubs.org

AlphaMissense for Identifying Pathogenic Missense Mutations in DNA Damage Repair Genes in Cancer

Relationship Among DNA Damage Response Gene Alterations, Molecular Subtypes, and Survival Outcomes in Patients With Metastatic Bladder Cancer Treated on CALGB 90601 Sequencing data from 56,965 ...
Fierce Biotech

Drug combo treats multiple cancers with ‘paradox’ mutation in mice

Carbone called BAP1 a “paradox” because of its seeming ability to both promote and slow cancer, depending on the ...
Medical Xpress

KRAS mutation type may guide more effective cancer treatments

KRAS is the most frequently mutated oncogene across all human cancers. Although different KRAS mutations have long been thought to exert the same cancer-driving effects, a new study led by UT ...
EurekAlert!

Groundbreaking study suggests that mutations driving evolution are informed by the genome, not random

A groundbreaking study published in this week’s issue of PNAS by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not randomly but more ...
Healio

Zongertinib a ‘breakthrough’ first-line treatment for NSCLC with HER2 mutations

Zongertinib provided substantial clinical benefit for patients with advanced or metastatic HER2-mutant advanced non-small cell lung cancer, surpassing the historical standard of care efficacy for this ...