Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

Genetic neurodegenerative disorders like Tay-Sachs and Sandhoff disease currently have no effective treatments. A possible strategy is replacing affected cells with healthy ones in order to slow the ...

SAN FRANCISCO, CA—In patients with neurological diseases like Alzheimer’s disease and multiple sclerosis, immune cells in the brain known as microglia that normally fulfill beneficial functions become ...

This image shows how human iPSCs in which the microglia-specifying six-TF cocktail is switched on (lower row), in contrast to iPSCs in which they remain switched off (upper row), abandon their ...