A newly identified crystal structure for an autoimmune TCR bound to peptide-MHC shows a highly unusual docking mode. Is this an anomaly or a new twist on MHC restriction? Figure 1: Unusual binding ...
Immunotherapies targeting peptides presented by allogeneic MHC molecules offer the prospect of circumventing tolerance to key tumor-associated self-antigens. However, the degree of antigen specificity ...
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