Nature

Defective MHC class I antigen surface expression promotes cellular survival through elevated ER stress and modulation of p53 function

The major histocompatibility complex (MHC) class I antigens are generally ubiquitously expressed and provide the identity to the host organism. 1, 2 Expression of these antigens on the cell surface ...
News Medical

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...
ascopubs.org

Quantitative MHC II protein expression levels in tumor epithelium to predict response to the PD1 inhibitor pembrolizumab in the I-SPY 2 Trial.

Tumor mutational burden (TMB) and PD-L1 expression as predictors of response to immunotherapy (IO) in NSCLC. This is an ASCO Meeting Abstract from the 2019 ASCO Annual Meeting I. This abstract does ...
ascopubs.org

LAG 3/MHC 2 and PD 1/PD L1 expression in non-small cell lung cancer patients.

Association of response to programmed death 1 receptor or ligand (PD1/PDL1) blockade with immune-related gene expression profiling across three cancer-types. This is an ASCO Meeting Abstract from the ...