Focusing on the schematic illustration in a, two DNA polymerase molecules are active at the fork at any one time. One moves continuously to produce the new daughter DNA molecule on the leading strand, ...

Undergraduate biology students could be forgiven for thinking that scientists have DNA replication all figured out. After all, textbooks present the models of replication so matter-of-factly that it's ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...

As DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

Overview: My research career was devoted to helping to establish the central principals of cellular DNA replication, ranging from mechanisms of nucleotide biosynthesis to the complex interplay of ...

This video shows replication of individual pieces of double stranded DNA. This is the first time DNA replication -- arguably, the fundamental process of life on Earth -- has been observed directly.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 11 (March 18, 2014), pp. 4073-4078 (6 pages) Replication of DNA plays a central role in transmitting ...

On their own, however, polymerases aren't good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand, and ...

Scientists at Indiana University (IU) have identified a genetic mechanism that is likely to drive mutations that can lead to cancer. Their E. coli study, published in the Proceedings of the National ...

During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...