Nature

Aseptic meningitis after intrathecal baclofen injection

To report an unusual complication of intrathecal baclofen injection during test injections. We present two cases of chemical meningitis after intrathecal baclofen injections by lumbar puncture. These ...
Nature

Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord

Gene delivery into the spinal cord provides a potential approach to the treatment of spinal cord traumatic injury, amyotrophic lateral sclerosis, and spinal muscular atrophy. These disorders progress ...
The American Journal of Managed Care

Subcutaneous Intrathecal Catheter Allows for Effective Administration of Nusinersen in SMA

A novel indwelling subcutaneous intrathecal catheter circumvented the complex spine anatomy of patients with spinal muscular atrophy (SMA), a challenge when giving nusinersen via intrathecal injection ...
Monthly Prescribing Reference

FDA: Risk of Inadvertent Intrathecal Administration of Tranexamic Acid Injection

Credit: FDA. The FDA has received reports of tranexamic acid injection being erroneously administered intrathecally in the perioperative setting instead of the intended intrathecal anesthetic (eg, ...
ascopubs.org

Toxicity and efficacy profiles of intrathecal injection of I-131 NaI via intraventricular (IVent) or intralumbar (Ilumb) route for leptomeningeal metastases (LM) therapy

Differences in the distribution of methotrexate into high grade gliomas following intravenous administration, as monitored by microdialysis, are associated with blood brain barrier integrity No ...