A team led by Prof. Dr. Dirk Haller has demonstrated for the first time that defective mitochondria cause injuries in the intestinal epithelium and influence the microbiome. In this microscopic image ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Attrition in the therapeutic pipeline is often linked to the gap in translational efficacy between the pre-clinical phase and clinical outcomes. Organoids offer strong potential for improving disease ...

What am I looking at? This video shows actin at work in a growing intestinal organoid. The video is depth-coded for color, which means that cooler colors like blue and purple are closer to the viewer ...

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at ...