The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at ...

Researchers have discovered a way to help aging intestines heal themselves using CAR T-cell therapy. By targeting senescent ...

As people live longer, the gut quietly accumulates damage that can tip the balance between healthy tissue renewal and chronic ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Researchers have found that CAR T-cell therapy can help aging intestines heal by targeting senescent cells. In mice, it ...

Researchers have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. A professor of pediatrics-developmental biology and an assistant professor of ...

Many people notice that certain foods become harder to tolerate with age. One possible reason is damage to the intestinal epithelium, a thin, single ...

mTOR, mammalian target of rapamycin; p70S6K, The 70kDa ribosomal S6 kinase 1; NLRP3, NOD-like receptor thermal protein domain associated protein 3; ASC, apoptosis-associated speck-like protein ...

Researchers have discovered a way to help aging intestines heal themselves using CAR T-cell therapy by targeting senescent cells that build up over time ...