'Inside-out' signalling causes integrins such as lymphocyte function-associated antigen 1 (LFA1; also known as αLβ2 integrin) to switch from a bent form to an extended form that more easily binds ...

In the absence of their cognate ligand, dependence receptors trigger programmed cell death. This function is the defining feature of dependence receptors, which include members of several different ...

This is a preview. Log in through your library . Abstract We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps ...