Drexel University

Instrumental Variable Methods for Cancer Comparative Effectiveness Studies: Do they help or hurt?

The department of Epidemiology and Biostatistics at Dornsife presents Nandita Mitra, PhD, professor of Biostatistics in the department of Biostatistics at University of Pennsylvania. Bias due to ...
ascopubs.org

Use of Instrumental Variable Analyses for Evaluating Comparative Effectiveness in Empirical Applications of Oncology: A Systematic Review

Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation Sixty-five empirical papers were ...
BMJ

Methods matter: instrumental variable analysis may be a complementary approach to intention-to-treat analysis and as treated analysis when analysing data from sports injury trials

Imagine a sports injury researcher claiming: ‘the effect of the injury prevention programme we reported in the trial is unbiased because we analysed according to the intention-to-treat principle’ (ITT ...
CMAJ

Outcomes of deliveries by family physicians or obstetricians: a population-based cohort study using an instrumental variable

Background: Previous research has suggested that obstetric outcomes are similar for deliveries by family physicians and obstetricians, but many of these studies were small, and none of them adjusted ...