The highly infectious nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely due to its affinity for mutations that continue to evolve and emerge throughout the current ...

Just like the mechanical components in cars or computers, the molecules inside a cell can sometimes malfunction. When this happens during DNA replication, the result is an unpredictable change in the ...

The Ins214EPE insertion mapped to the N-terminal domain (NTD) of Omicron S, close to the site of a known human T-cell epitope on SARS-CoV-2. Hence, further research should investigate whether ...

The drug, amivantamab, is a treatment for non-small cell lung cancer (NSCLC). The FDA decision Friday covers adults whose disease is characterized by an exon 20 insertion mutation to epidermal growth ...

Activating mutations on the EGFR protein, including exon 20 insertion mutations, have a role in NSCLC, but the associated structural changes resulting from the V769insASV and D770insNPG EGFR exon 20 ...

A man with lung cancer shares how learning about his EGFR exon 20 insertion mutation soon after being diagnosed has allowed him to be aggressive when pursuing a cancer treatment tailored to his rare ...

Credit: Getty Images. A PDUFA target date of November 24, 2022 has been set for the application. The Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for ...

Credit: FDA. According to the CRL, the application could not be approved in its present form as additional data, including a randomized controlled trial, would be required. The Food and Drug ...