The complement system in teleost fish constitutes a cornerstone of innate defence, integrating classical, lectin and alternative activation routes to eliminate pathogens and shape inflammatory ...

The complement cascade, a cornerstone of innate immunity, has been increasingly recognised for its non-canonical role in sculpting neural circuits through synaptic pruning. Central to this process is ...

The immune system has two separate responses, which are orchestrated to optimize protection against pathogens. The first response is known as innate immunity. This first wave of protection provides ...

A new review by Dr. Ruyuan Wang and an international team of researchers explores the complex interactions between the innate and adaptive immune systems, shedding light on regulatory mechanisms in ...

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American The very first line of defence against any ...

Researchers have discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system, a key component of early antiviral immunity. This significantly ...

Humans are protected by two branches of the immune system. Innate immunity provides built-in defense against widespread characteristics of bacteria and viruses, while adaptive immunity memorizes ...

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...

Louse-borne relapsing fever is an acute bacterial infection that triggers recurring episodes of high fever. It is caused by the spirochete Borrelia recurre | Immunology ...

Dozens of new discoveries reveal that defenses evolved by bacteria and viruses billions of years ago still define our own innate immune system. Evolutionary arms races — where one species is pitted ...

The innate response's job is to assess the threat and determine how best to handle it. When it has a firm grasp on the situation, and if it can't deal with the threat itself, the innate response ...