First off, I'm very picky when it comes to mice. I can't stand the Apple-style acceleration curve. Never have, probably never will. I have always used apps like Steermouse to tweak the mice on my macs ...
For years, I never used the extra buttons on the side of my mouse, and mostly just viewed them as a nuisance. Too often I’d click them by accident and trigger some unwanted action, like navigating ...