Genes that encode G-protein-coupled receptors (GPCRs) and G proteins can have loss-of-function or gain-of-function mutations, which result in endocrine disorders Loss-of-function mutations in GPCRs ...

G protein-coupled receptors (GPCRs) are targeted by ∼30–40% of marketed drugs, and their key roles in normal physiology and in disease demonstrate that an understanding of their structure and function ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...