However, a G2 checkpoint can be activated by parallel pathways (Passalaris et al., 1999; Chan et al., 2000) including DNA damage-independent pathways (Smith et al., 2002), and some p53-deficient cells ...
Checkpoints are control mechanisms that ensure the proper timing of cell cycle events by enforcing the dependency of late events on the completion of early events (Hartwell and Weinert, 1989). Entry ...
The maximum tolerated dose and biologic effects of 3-amino-pyridine-2-carboxaldehyde thiosemicarbazone (T) in combination with irinotecan (I) for patients with refractory solid tumors This is an ASCO ...
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