The authors describe a method-validation-by-design (MVbD) approach to validate a method over a range of formulations using both design-of-experiment and quality-by-design principles to define a design ...

Chemical engineers have devised a simpler process for incorporating hydrophobic drugs into tablets or other drug formulations, using nanoemulsions. With this method, it may be possible to make many ...

Nonclinical dose formulation analysis methods are used to confirm test article concentration and homogeneity in formulations and determine formulation stability in support of regulated nonclinical ...

Lipid nanoparticle formulation has increased over the past two decades. LNPs have proven to be effective nano-based delivery vehicles for cytotoxic chemotherapeutic drugs, nucleic acid therapies and ...

SIAM Journal on Numerical Analysis, Vol. 35, No. 2 (Apr., 1998), pp. 560-571 (12 pages) A new mixed finite element method is formulated for the Stokes equations, in which the two components of the ...

CAMBRIDGE, MA -- About 60 percent of drugs on the market have hydrophobic molecules as their active ingredients. These drugs, which are not soluble in water, can be difficult to formulate into tablets ...