The promise of biotechnology is tempered by its potential for accidental or deliberate misuse. Reliably identifying telltale signatures characteristic to different genetic designers, termed ‘genetic ...
In a new study published in Nature titled, “Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning,” researchers from Massachusetts General Hospital (MGH) and Harvard Medical ...
Here we undertook a scalable protein engineering campaign to deeply profile the contribution of SpCas9 PAM-interacting (PI) domain amino acids to the PAM requirement. By generating experimental PAM ...
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