Surface plasmon resonance (SPR) detectors monitor molecular interactions without labels and in real time. SPR imaging (SPRi) has the additional advantage of increased throughput since it monitors ...

Congestive heart failure is a disease state distinguished by the regular presence of both renal and hepatic abnormalities in drug handling. One such abnormality involves flaws in the process of drug ...

Though studies evaluating the effects of posture on the absorption of drugs have been conducted, a systematized review revealed critical gaps in methodology. Of 18 original research articles selected ...

Passive diffusion plays an essential role in oral absorption of drugs through the gastrointestinal tract, penetration across the blood-brain barrier to reach Central Nervous System disease targets, ...

New research shows that certain flavonols from everyday foods can shut down the body’s drug-resistance machinery, potentially paving the way for more effective treatments, but clinical hurdles remain.

Highly potent but poorly water-soluble drug (PWSD) candidates are common outcomes of contemporary drug discovery programmes. These lipophilic compounds often exhibit poor systemic exposure following ...

Before orally administered drugs can make their way throughout the body, they must first bind to membrane proteins called drug transporters, which carry compounds across the intestinal tract and help ...

The NMR and Drug Metabolism Core has developed rapid and efficient approaches to investigate metabolism, metabolic stability, pharmacokinetics (PK), and chemical structure identification of small ...

Absorption promoters and enhancers and enzyme inhibitors, either alone or in combination, can play an important role in improving the bioavailability of oral insulin. The early years of oral insulin ...

The use of the lungs for the systemic delivery of medicines is virtually unexploited, and the ancient human practice of inhaling substances for systemic effect (with the exception of anaesthetic gases ...

This review highlights relevant physicochemical drug properties and formulation design considerations critical to quality and performance of the sublingual tablets. The oral mucosal lining offers a ...

There exists a unique and clinically relevant time course of urinary drug delivery for a loop diuretic at which the natriuretic response is optimized. This rate of drug delivery resides on the steep ...