In 1997, Brad Pitt and Harrison Ford teamed up for what should have been an easy win in The Devil’s Own. Well, turns out, behind the scenes was as twisty as the movie’s plot. Script? Tossed out.

The box-office megastar status and heroic screen persona that Harrison Ford maintained in the 1980s and 1990s seemingly precluded him from sharing top billing with fellow superstars. The first ...

Pakula had previously directed Ford in 1990’s “Presumed Innocent.” In “The Devil’s Own,” Pitt plays a member of the Provisional Irish Republican Army who comes to the United States seeking ...

A key lesson one can learn from experience in designing clinical trials is that the devil is often in the details. Trial design is equally as important as—if not more important than—trial execution.