Scientists have reached a new milestone in decoding the human genome, unlocking complex regions once believed to be too difficult to study. Researchers used long-read sequencing to analyze the DNA of ...

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

A landmark study harnesses long-read sequencing to reveal vast, previously undetected structural variations in human DNA, reshaping our understanding of genetics and disease potential. Study: ...

Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from embryonal ...

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought. The ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

A blood test clarifies which gene variants truly cause congenital heart defects, linking diagnosis to more precise ...

Cucumber is an economically important crop worldwide, ranking as the third most-produced vegetable after tomatoes and onions. Yet breeding improved varieties—plants that are more resilient, produce ...

[more than 13% of patients with advanced NSCLC and an aSV] "would have experienced a meaningful delay of several weeks or more if RNA-NGS and DNA-NGS had been performed sequentially rather than ...