A fundamental goal of modern biology is building models that can infer phenotype from genotype. Such models are also key to a mechanistic understanding of disease heterogeneity and to tailoring ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics-meticulously placed chemical tags that influence which genes are expressed in ...

Single-molecule fluorescence techniques have been successfully applied to uncover the structure, dynamics and interactions of DNA, RNA and proteins at the molecular scale. While the structure and ...

“We’re only just beginning to understand the full majesty of life on Earth,” wrote the founding members of the Earth BioGenome Project in 2018. The ambitious project raised eyebrows when first ...

DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...