Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...

After two decades in the making, scientists have cracked the code on a drug that can repair DNA, setting the scene for a new class of therapeutics that can fix tissue damage that occurs through heart ...

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, ...

Targeted DNA editing by CRISPR technology has great potential for applications in biotechnology and gene therapy. However, precise gene editing remains a challenge largely due to insufficient control ...

Using comparative molecular biology with human cGAS – which actually inhibits DNA repair – the scientists found that the naked mole-rat's enzyme has four key changes that facilitate the important work ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

For decades, biology textbooks taught that DNA’s story could be told with a single image: two elegant strands twisting in a ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...