Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division - a discovery that could lead to new cancer therapies, according ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

DNA replication is a tightly controlled process that copies the genetic code, allowing its instructions to be conveyed from one generation of cells to the next. In diseases like cancer, these ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...