TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the pathomechanisms ...
Pore-forming toxins (PFTs) are a diverse class of proteins capable of disrupting cell membranes through the formation of transmembrane channels. These molecular machines play a central role in both ...
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