Early in the drug discovery process, it is necessary to begin studies on enantiomerically pure compounds due to the potential for unique efficacy and adverse effects associated with one enantiomer ...

Atropisomers are a class of stereoisomers (chemical compounds that differ in spatial arrangement of atoms) arising from restricted rotation around a single bond and have various applications in ...

Metals like rhodium and palladium are C–H activation aces, but these metals are rare and expensive. For several years, chemists led by Lutz Ackermann at the Georg August University Göttingen have been ...

Chemists from the National University of Singapore (NUS) have conceived a strategy using chiral nickel catalysts to facilitate the carboboration of alkenes, generating high-value enantioenriched ...

Many pharmaceuticals need to be a certain shape to fit into the binding pocket of the enzyme they target. Synthesizing molecules with the desired chirality requires controlled addition of functional ...

Chirality, or "handedness," is a fundamental property of objects, from galaxies to molecules, and plays a crucial role in biological systems. However, chiral compounds in living organisms such as ...

Modern chiral stationary phases allow rapid ER analysis and are applied to separate a wide range of chiral compounds. ER determination via chiral stationary phases allows facile assignment of absolute ...

The recognition of chirality in bioactive molecules is as old as modern organic chemistry itself. Pioneering work by Jean-Baptiste Biot, Louis Pasteur, Emil Fischer, and J. vant Hoff established ...