Retrospective analyses of clinical tumor samples identify TGFβ1 as the most prevalent TGFβ isoform in most solid cancers Preclinical results demonstrate highly selective inhibition of TGFβ1 activation ...
CLEC-1 is a death receptor and binds to dead cells induced by secondary necrosis. We have discovered that CLEC-1 represents a novel type of myeloid checkpoint within the C-Type Lectin family ...
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